I'm afraid a guy called Godel and his Incompleteness theorem precludes us from having a theory of everything finally being discovered, it's affectionately acronymed as TOE.
Godel was a smart guy, both a mathematician and a philosopher; and is best known for his incompleteness theorem which in basic terms prevents mathematics from proving certain propositions true or false by using the rules of that particular area itself.
It sounds a bit up its own ass but some people have described Godel's work as one of the most important in mathematics/science.
Its relevance here is that the rules and axioms we use in science to understand and frame the world in which we live, ultimately determine there are things about our world that we cannot ever know using the scientific rules we have available to us.
And so, there will be no 'Road to Damascus' epiphany for science in terms of theories of everything being validated, we'll have to live in ignorance and perhaps that is a preferable place for us ....I qiute like the mystery of not knowing, science thrives on it