Personally, I like being in a 2 on 1, simply because I know what they are going to do. They know they don't want to just trade paint with you, beause they know you have 2 targets to shoot at, and odds are one of them is going to make a mistake before you. Thus, they will either try to spread wide across the field and angle you out, or try to pin you down and mug you. For the former, just play smart, and sweetspot one of them as they are moving. If they try to take you down, do not let yourself get pinned in, and pop the guy that tries to mug you.
Whatever you do, realize that a 2 on 1 is paintball at its best. Just you, your wits, and some massive cajones against 2 opponents who can already taste their victory. There is no better feeling in the game then taking out those 2 fools who didn't give you enough respect, and lost because of it.