I have heard some players have attatched an ASA to the bottle ,and leaving the on/off screw screwed in for the purpose of air travel.
Thus the bottle will be under no pressure when up in high altittudes.
But if you do decide to have someone or yourself to take the reg off, its easy to put back on/off again without the locktite. Becareful when not using locktite on the threads, even low pressure at say 400/500 psi, its still easy to screw the bottle off the reg when trying to take tank off the marker.